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How to Change Your Mind
Cover of How to Change Your Mind
How to Change Your Mind
What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence
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“Pollan keeps you turning the pages . . . cleareyed and assured.” —New York Times
A #1 New York Times Bestseller, New York Times Book Review 10 Best Books of 2018, and
 New York Times Notable Book 
A brilliant and brave investigation into the medical and scientific revolution taking place around psychedelic drugs—and the spellbinding story of his own life-changing psychedelic experiences

When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists inadvertently catalyzed a powerful backlash against what was then a promising field of research.
A unique and elegant blend of science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's "mental travelogue" is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both suffering and joy, we can do our best to be fully present and find meaning in our lives.
“Pollan keeps you turning the pages . . . cleareyed and assured.” —New York Times
A #1 New York Times Bestseller, New York Times Book Review 10 Best Books of 2018, and
 New York Times Notable Book 
A brilliant and brave investigation into the medical and scientific revolution taking place around psychedelic drugs—and the spellbinding story of his own life-changing psychedelic experiences

When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists inadvertently catalyzed a powerful backlash against what was then a promising field of research.
A unique and elegant blend of science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's "mental travelogue" is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both suffering and joy, we can do our best to be fully present and find meaning in our lives.
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    Prologue

    Midway through the twentieth century, two unusual new molecules, organic compounds with a striking family resemblance, exploded upon the West. In time, they would change the course of social, political, and cultural history, as well as the personal histories of the millions of people who would eventually introduce them to their brains. As it happened, the arrival of these disruptive chemistries coincided with another world historical explosion—that of the atomic bomb. There were people who compared the two events and made much of the cosmic synchronicity. Extraordinary new energies had been loosed upon the world; things would never be quite the same.

    The first of these molecules was an accidental invention of science. Lysergic acid diethylamide, commonly known as LSD, was first synthesized by Albert Hofmann in 1938, shortly before physi- cists split an atom of uranium for the first time. Hofmann, who worked for the Swiss pharmaceutical firm Sandoz, had been looking for a drug to stimulate circulation, not a psychoactive compound. It wasn’t until five years later when he accidentally ingested a minus- cule quantity of the new chemical that he realized he had created something powerful, at once terrifying and wondrous.


    The second molecule had been around for thousands of years, though no one in the developed world was aware of it. Produced not by a chemist but by an inconspicuous little brown mushroom, this molecule, which would come to be known as psilocybin, had been used by the indigenous peoples of Mexico and Central America for hundreds of years as a sacrament. Called teonanácatl by the Aztecs, or “flesh of the gods,” the mushroom was brutally suppressed by the Roman Catholic Church after the Spanish conquest and driven un- derground. In 1955, twelve years after Albert Hofmann’s discovery of LSD, a Manhattan banker and amateur mycologist named R. Gordon Wasson sampled the magic mushroom in the town of Huautla de Jiménez in the southern Mexican state of Oaxaca. Two years later, he published a fifteen-page account of the “mushrooms that cause strange visions” in Life magazine, marking the moment when news of a new form of consciousness first reached the general public. (In 1957, knowledge of LSD was mostly confined to the com- munity of researchers and mental health professionals.) People would not realize the magnitude of what had happened for several more years, but history in the West had shifted.

    The impact of these two molecules is hard to overestimate. The advent of LSD can be linked to the revolution in brain science that begins in the 1950s, when scientists discovered the role of neu- rotransmitters in the brain. That quantities of LSD measured in mi- crograms could produce symptoms resembling psychosis inspired brain scientists to search for the neurochemical basis of mental dis- orders previously believed to be psychological in origin. At the same time, psychedelics found their way into psychotherapy, where they were used to treat a variety of disorders, including alcoholism, anxi- ety, and depression. For most of the 1950s and early 1960s, many in the psychiatric establishment regarded LSD and psilocybin as miracle drugs.


    The arrival of these two compounds is also linked to the rise of the counterculture during the 1960s and, perhaps especially, to its particular tone and style. For the first time in history, the young had a rite of passage all their own: the “acid trip.” Instead of folding the young into the adult world, as rites of passage have always done, this one landed them in a country of the mind few adults...

Reviews-
  • Library Journal

    December 1, 2017

    Before Timothy Leary encouraged Sixties counterculturalists to turn on, tune in, and drop out, scientists and doctors saw LSD and other psychedelics as tremendous new tools for understanding consciousness. Now, these back-burnered drugs are proving effective in treating such disorders as PTSD and depression. New York Timesbest-selling author Pollan even put himself forth as guinea pig.

    Copyright 2017 Library Journal, LLC Used with permission.

  • Kirkus

    March 1, 2018
    Noted culinary writer Pollan (Cooked: A Natural History of Transformation, 2013, etc.) makes the transition from feeding your body to feeding your head.The lengthy disclaimer on the copyright page speaks volumes. The author, well-known for books on food and life such as The Botany of Desire and The Omnivore's Dilemma, has been opening some of the doors of perception with the aid of lysergic acid, its molecular cousin psilocybin, ayahuasca, and assorted other chemical tools. His journeys are timely, since, "after several decades of suppression and neglect, psychedelics are having a renaissance." For one thing, LSD and its kin have proven potent tools in treating depression, anxiety, addictions, post-traumatic stress, and other ailments. Through the use of neuroimaging technologies that were not available to the pioneers of psychiatric psychedelia, we can see that in interrupting ordinary patterns of thought and helping regroove the brain, these drugs are in fact mind-expanding, as the "hoary 1960s platitude" would have it. Pollan traveled deep into the woods to undertake acid-laced spirit journeys with people who are off the grid, and perhaps a touch off their rockers as well; at the Esalen Institute, he learned the latest from a place that served a historic role in spreading the psychedelic gospel. As Pollan notes, there are risks in unguided forays into the dustier corners of the mind, but the old scare tactics of chromosomal damage and going blind after staring at the sun are just that--though, as he also writes, "once introduced into the culture, these urban legends survive and, on occasion, go on to become 'true.' " The author's evenhanded but generally positive approach shoos away scaremongering while fully recognizing that we're out in the tall grass--and, as he notes, though credited with psychological evenness, he's found himself "tossed in a psychic storm of existential dread so dark and violent that the keel comes off the boat," reason enough to seek chemical aid.A trip well worth taking, eye-opening and even mind-blowing.

    COPYRIGHT(2018) Kirkus Reviews, ALL RIGHTS RESERVED.

  • Publisher's Weekly

    Starred review from March 12, 2018
    Food writer Pollan (Cooked) shifts his focus to other uses of plants in this brilliant history of psychedelics across cultures and generations, the neuroscience of its effects, the revival of research on its potential to heal mental illness—and his own mind-changing trips. For an entire generation, psychedelics were synonymous with Harvard professor-turned-hippie Timothy Leary and his siren call to “turn on, tune in, drop out.” But, Pollan argues, that freewheeling attitude quickly turned into a “full-on moral panic about LSD” that “doomed the first wave of research.” By the 1990s, the body of knowledge about the successful use of LSD to treat alcoholics in the ’50s and ’60s was buried, and medical interest only revived in 2010 with studies on treating cancer anxiety with psilocybin. Pollan writes movingly of one man whose “psychedelic journey had shifted his perspective from a narrow lens trained on the prospect of dying to a renewed focus on how best to live the time left to him.” Today, renewed interest has sent scientists racing ahead with trials of psychedelics to treat addiction and depression, and curious seekers like Pollan into experiments with these substances. This nuanced and sophisticated exploration, which asks big questions about meaning-making and spiritual experience, is thought-provoking and eminently readable. Agent: Amanda Urban, ICM.

  • Library Journal

    April 15, 2018

    Journalist and author Pollan (Univ. of California Berkeley Graduate Sch. of Journalism; The Omnivore's Dilemma) dives into the history, science, and mystery of psychedelics: the infamous category of "mind manifesting" substances at once fairly and unfairly associated with 1960s counterculture. Today psychedelics are experiencing a renaissance in scientific research and culture, which shows promising signs of both unraveling past stereotypes and developing new approaches to the brain, consciousness, and treatments for mental illness. To illustrate this shift, Pollan presents a variety of perspectives, including his own "travelog" of forays with LSD and more. The result is a mixture of captivating journalism and unfortunately slightly awkward storytelling; the latter a consequence of the author's occasional discomfort with his own relationship to the topic. This book can set one a little off-kilter but is true to its ultimate goal: to get readers to open their minds and consider what psychedelics might yet teach us about ourselves and what we don't know. VERDICT A work of participatory journalism that shines new light on psychedelics and the people who study them. Recommended for fans of Pollan, science journalism, and studies of the mind.--Robin Chin Roemer, Univ. of Washington Lib., Seattle

    Copyright 2018 Library Journal, LLC Used with permission.

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How to Change Your Mind
How to Change Your Mind
What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence
Michael Pollan
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